Scientists found that DNA once dismissed as “junk” helps chromosomes find their partners | timesofindia.indiatimes.com

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Scientists found that DNA once dismissed as “junk” helps chromosomes find their partners | timesofindia.indiatimes.com
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For years, the dense loops of repetitive DNA clustered near the middle of chromosomes were treated as evolutionary clutter. According to the new study published in Nature, titled ‘Meiotic pairing through barcode-like satellite DNA repeats‘, researchers working with fruit flies have shown that this so-called satellite DNA forms a kind of barcode: a unique combination of repeats that lets each chromosome recognise its correct partner during the formation of egg cells. When that barcode is disrupted, chromosomes pair with the wrong partner or fail to pair at all, and the eggs carrying that error are frequently destroyed by the body’s own quality-control system before they can mature. The discovery revives an idea first floated nearly fifty years ago and offers the clearest evidence yet that “junk” DNA plays a direct hand in one of reproduction’s most exacting steps.

Every cell that produces eggs or sperm must first sort its chromosomes into matching pairs, lining up each one with its homologous partner before they exchange genetic material. According to the research team, fruit flies carry at least 19 distinct satellite DNA repeats scattered unevenly across their four chromosome pairs. Because each chromosome pair ends up with its own particular combination of these repeats, the arrangement effectively works as an identifying tag, a barcode built entirely from non-coding sequence.The idea that these repeats might guide pairing was first proposed roughly fifty years ago, but earlier experiments deleting satellite DNA from a single chromosome failed to produce any obvious defects, leading many researchers to dismiss the theory.

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